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α-Pyrone derivatives with cyto-protective activity from two Takla Makan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium

Author:
Zhao, Tingting, Chang, Yimin, Zhu, Tianjiao, Li, Jing, Gu, Qianqun, Li, Dehai, Che, Qian, Zhang, Guojian
Source:
Natural product research 2019 v.33 no.17 pp. 2498-2506
ISSN:
1478-6427
Subject:
Nocardiopsis, desert soils, enzymes, metabolic detoxification, nuclear magnetic resonance spectroscopy, seawater, soil sampling
Abstract:
In this paper, we described the discovery of two Nocardiopsis strains HDN154-146 and HDN154-168 from Takla Makan desert soil samples using seawater based medium. Chemical investigation of these two strains led to the discovery of eight new α-pyrone derivatives named nocahypyrones A-H (1–8), together with one known analogue germicidin G (9). The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Compounds 1–9 were tested for their cyto-protective activities and for the first time we found α-pyrones 5 and 8 exhibited capabilities to induce expression of phase II detoxifying enzymes.
Agid:
6489032