PubAg

Main content area

Metal-free visible-light induced cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones and diselenides: access to 5-hydroxy-3-selenyl-4a,8a-dihydro-2H-chromen-6(5H)-ones

Author:
MaXian-Li Ma and Qian Wang contributed equally to this work., Xian-Li, Wang, Qian, Feng, Xi-Yuan, Mo, Zu-Yu, Pan, Ying-Ming, Chen, Yan-Yan, Xin, Mao, Xu, Yan-Li
Source:
Green chemistry 2019 v.21 no.13 pp. 3547-3551
ISSN:
1463-9270
Subject:
antineoplastic activity, cell growth, cyclization reactions, green chemistry, hydrolysis, light, toxicity testing
Abstract:
A simple and efficient Se-radical triggered cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones to afford 5-hydroxy-3-selenyl-4a,8a-dihydro-2H-chromen-6(5H)-ones has been developed. This transformation via the 3,5-diselenyl-4a,8a-dihydro-2H-chromen-6(5H)-one intermediate followed by hydrolysis in the presence of CsOAc affords the desired product 3. The resulting products were tested for their in vitro anticancer activity using MTT assay, and compounds 3e and 3q showed potent cancer cell-growth inhibition activities.
Agid:
6489109