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Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved

Author:
Di Gaetano, Sonia, Bedini, Emiliano, Landolfi, Alfredo, Pedone, Emilia, Pirone, Luciano, Saviano, Michele, Traboni, Serena, Capasso, Domenica, Iadonisi, Alfonso
Source:
Carbohydrate research 2019 v.482 pp. 107740
ISSN:
0008-6215
Subject:
carcinoma, cell lines, cervix, cytotoxicity, fibroblasts, fucose, galactose, galectins, glucosamine, ligands, melanoma, moieties, neoplasm cells, receptors, sulfides, sulfur
Abstract:
A mini-library of symmetrical and unsymmetrical diglycosyl (di)sulfides, containing d-galactose, l-fucose and N-acetyl glucosamine units, were synthesized and tested for the antiproliferative activity against cervix carcinoma (HeLa) and melanoma (A375) tumor cell lines as well as healthy fibroblasts (HDF). Comparative analysis of results seems to indicate that the most relevant antiproliferative effect is not primarily influenced by interactions with galectins, as the most cytotoxic compound observed for HeLa and A375 is not a ligand for such receptors. The most active molecules against HeLa and A375 lines also exhibited a good selectivity, showing a low toxicity to HDF cells. Obtained results offer useful indications for future design of structurally simple antitumor molecules based on sugar moieties with bridging sulfur atoms.
Agid:
6494154