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Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats

Hsieh, Yu Shan, Shin, You Kyoung, Han, A Young, Kwon, Soonho, Seol, Geun Hee
Life sciences 2019 v.232 pp. 116608
acetates, animal disease models, blood serum, hypertension, interleukin-6, lactate dehydrogenase, malondialdehyde, necrosis, neoplasms, patients, rats, respiratory tract diseases, systolic blood pressure, tumor necrosis factor-alpha
Preventing vascular damage is considered an effective strategy in patients who suffer from chronic obstructive pulmonary disease (COPD) with hypertension. Here, we investigated vascular damage in COPD-like and hypertensive rats, which demonstrated the presence of the three related factors of COPD with hypertension. These include elevated systolic blood pressure (SBP), serum malondialdehyde (MDA) and serum lactate dehydrogenase (LDH), which are positively correlated with vascular damage in patients. In addition to increases in these three related factors, COPD-like and hypertensive rats exhibited increased levels of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-6, and matrix metallopeptidase-9 in bronchoalveolar lavage fluid, and enlargement of alveolar airspaces, recapitulating clinical findings in previous studies of patients. Moreover, the appearance of these related factors was prevented by linalyl acetate. Our results provide novel insight into the potential of LA to prevent vascular damage and elevated SBP, serum MDA and serum LDH in COPD with hypertension, and could lead to an alternative strategy for preventing vascular damage for patients who suffered from COPD with hypertension in a clinical setting.