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Synthesis of the C1–C13 fragment of eribulin mesylate

Author:
Lee, Hyoseon, Park, Yongseo, Jung, Heesun, Kim, Seong Take, Sin, Seunghui, Ko, Eunjung, Myeong, In-Soo, Moon, Hyoungwook, Suhl, Chang Heon, Jung, Yunkyung, Jung, Eunim, Lee, Junkyu, Lee, Kee-Young, Oh, Chang-Young, Song, Jooyoung, Yoon, Soo Hwan, Kang, Wonjae, Jung, Jaehun, Shin, Hyunik
Source:
Tetrahedron 2019 v.75 no.33 pp. 4570-4576
ISSN:
0040-4020
Subject:
chemical structure, epoxidation reactions, olefin, regioselectivity, stereoselectivity
Abstract:
Synthesis of the C1–C13 fragment of eribulin mesylate has been accomplished. It features a highly stereoselective construction of a trans-dihydropyran framework using three key reactions: (1) Sharpless epoxidation, (2) regioselective ring opening, and (3) olefin metathesis.
Agid:
6494433