Main content area

A galactoglucan isolated from of Cistanche deserticola Y. C. Ma. and its bioactivity on intestinal bacteria strains

Zeng, Hui, Huang, Lulin, Zhou, Lishuang, Wang, Peipei, Chen, Xia, Ding, Kan
Carbohydrate polymers 2019 v.223 pp. 115038
Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Cistanche deserticola, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus reuteri, bioactive properties, drugs, galactose, glucose, homeostasis, humans, intestinal microorganisms, intestines, molecular weight, polysaccharides, probiotics
To understand whether polysaccharides may have impact on gut microbiota, a neutral polysaccharide CDA-0.05 with an average molecular weight of 7.96 kDa was obtained from Cistanche deserticola Y. C. Ma. The monosaccharide composition analysis indicated that CDA-0.05 was composed of glucose and galactose in a molar ratio of 96.4: 3.6. The backbone of CDA-0.05 contained 1, 4-linked α-D-Glcp, 1, 4, 6-linked α-D-Glcp and 1, 4-linked β-D-Galp, with branches of T-linked α-D-Glcp attached at C-6 of 1, 4, 6-linked α-D-Glcp residues. Bioactivity test results suggested that CDA-0.05 could promote the growth of three species of Bacteroides (B. thetaiotaomicron, B. ovatus and B. fragilis) significantly. Furthermore, CDA-0.05 could also promote some probiotics growth, such as Lactobacillus casei, Lactobacillus plantarum and Lactobacillus reuteri. These results suggested that CDA-0.05 might help to maintain intestinal homeostasis and could be recommended as part of fibers or drugs candidate to benefit human body by regulating gut bacteria.