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Biogenic Trichoderma harzianum-derived selenium nanoparticles with control functionalities originating from diverse recognition metabolites against phytopathogens and mycotoxins

Hu, Dongqiang, Yu, Song, Yu, Dianzhen, Liu, Na, Tang, Yan, Fan, Yingying, Wang, Cheng, Wu, Aibo
Food control 2019 v.106 pp. 106748
Alternaria, Trichoderma harzianum, adverse effects, antifungal properties, biological control, biosynthesis, deoxynivalenol, drug therapy, food safety, fumonisin B1, fungi, genes, glucaric acid, lactones, mass spectrometry, metabolites, nanoparticles, organic acids and salts, plant pathogens, plant protection, selenium
Selenium nanoparticles (SNP) were generally utilized as chemotherapeutic agents and environmental ameliorants, but without simultaneous biocontrol functionalities against fungal pathogens and mycotoxins, plus unknown recognition mechanism. Selenium nanoparticles derived from Trichoderma harzianum JF309 (TSNP) were herein synthesized, contrast to traditional SNP, where diverse metabolites co-occurred in TSNP including organic acids and their derivates, such as psoromic acid, β-decyloxybenzoic acid, glucaric acid lactone, etc., revealed by Triple TOF UPLC/HRMS. As hypothesized, this interaction of diverse recognition metabolites and selenium nanoparticles in TSNP might change the arrangement and movement of original state, form random, nondirective to regulated, directional, thus contributing to better antifungal effects and dramatically increasing control functionalities against Alternaria toxins (83% of TeA and 79% of AOH reduction), fumonisin B1 (63% of FB1 reduction) and deoxynivalenol (76% of DON reduction), respectively. Meanwhile, expression of key biosynthetic genes of FUM1, PA, TRI5 and TRI6 were substantially decreased. Finally, as convinced, the obtained nanoparticles had no significant side effects to the selected three human cells. In total, the achieved data supports the biogenic nanoparticles as valuable functional materials with great potential for practical plant protection and food safety prevention.