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An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis
- Liu, Jin-Yu, Yang, Xie-Chao, Liu, Zhen, Luo, Yong-Chun, Lu, Hong, Gu, Yu-Cheng, Fang, Ran, Xu, Peng-Fei
- Organic letters 2019 v.21 no.13 pp. 5219-5224
- catalysts, catalytic activity, chemical reactions, chemical structure, hydrogen bonding, indoles
- A variety of axially chiral biaryldiols were synthesized in good yields with excellent atropo-enantioselectivities through construction of axially chiral indoles catalyzed by asymmetric hydrogen-bond donors. In addition, the new axially chiral compounds were proved to be efficient and practical catalysts for asymmetric catalysis. The strategy not only provides a novel method to synthesize axially chiral compounds but also extends the scope of chiral catalysts.