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Palladium catalyzed regioselective elimination–hydrocarbonylation of propargylic alcohols

Author:
Yuan, Yuan, Jia, Minqiang, Zhang, Wanli, Ma, Shengming
Source:
Chemical communications 2019 v.55 no.55 pp. 7938-7941
ISSN:
1364-548X
Subject:
alcohols, carboxylic acids, catalytic activity, chemical bonding, chemical reactions, palladium, regioselectivity
Abstract:
A straightforward approach to synthesizing substituted 1,3-alkadien-2-yl carboxylic acids starting from readily available propargylic alcohols was developed. Based on mechanistic studies, the reaction was found to proceed via regioselective hydrocarbonylation of the C–C triple bonds of the in situ formed 1,3-enyne intermediates, providing 1,3-alkadien-2-yl carboxylic acids with a very high selectivity.
Agid:
6497419