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Two New Spiro-Heterocyclic <i>γ</i>-Lactams from A Marine-Derived <i>Aspergillus fumigatus</i> Strain CUGBMF170049

Author:
Xu, Xiuli, Han, Jiahui, Wang, Yanan, Lin, Rui, Yang, Haijin, Li, Jiangpeng, Wei, Shangzhu, Polyak, Steven W., Song, Fuhang
Source:
Marine drugs 2019 v.17 no.5
ISSN:
1660-3397
Subject:
Aspergillus fumigatus, circular dichroism spectroscopy, fermentation, fungi, mass spectrometry, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Two new spiro-heterocyclic &gamma;-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds.
Agid:
6497828