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High-Fructose Corn-Syrup-Sweetened Beverage Intake Increases 5-Hour Breast Milk Fructose Concentrations in Lactating Women

Berger, Paige K., Fields, David A., Demerath, Ellen W., Fujiwara, Hideji, Goran, Michael I.
Nutrients 2018 v.10 no.6
beverages, breast milk, cross-over studies, fasting, fructose, glucose, high fructose corn syrup, lactating women, lactose, mothers
This study determined the effects of consuming a high-fructose corn syrup (HFCS)-sweetened beverage on breast milk fructose, glucose, and lactose concentrations in lactating women. At six weeks postpartum, lactating mothers (n = 41) were randomized to a crossover study to consume a commercially available HFCS-sweetened beverage or artificially sweetened control beverage. At each session, mothers pumped a complete breast milk expression every hour for six consecutive hours. The baseline fasting concentrations of breast milk fructose, glucose, and lactose were 5.0 &plusmn; 1.3 &micro;g/mL, 0.6 &plusmn; 0.3 mg/mL, and 6.8 &plusmn; 1.6 g/dL, respectively. The changes over time in breast milk sugars were significant only for fructose (treatment &times; time, p < 0.01). Post hoc comparisons showed the HFCS-sweetened beverage vs. control beverage increased breast milk fructose at 120 min (8.8 &plusmn; 2.1 vs. 5.3 &plusmn; 1.9 &micro;g/mL), 180 min (9.4 &plusmn; 1.9 vs. 5.2 &plusmn; 2.2 &micro;g/mL), 240 min (7.8 &plusmn; 1.7 vs. 5.1 &plusmn; 1.9 &micro;g/mL), and 300 min (6.9 &plusmn; 1.4 vs. 4.9 &plusmn; 1.9 &micro;g/mL) (all p < 0.05). The mean incremental area under the curve for breast milk fructose was also different between treatments (14.7 &plusmn; 1.2 vs. &minus;2.60 &plusmn; 1.2 &micro;g/mL &times; 360 min, p < 0.01). There was no treatment &times; time interaction for breast milk glucose or lactose. Our data suggest that the consumption of an HFCS-sweetened beverage increased breast milk fructose concentrations, which remained elevated up to five hours post-consumption.