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Re-isolation of Marek’s disease virus from T cell subsets of vaccinated and non-vaccinated chickens

Author:
Lee, S.-I., Ohashi, K., Morimura, T., Sugimoto, C., Onuma, M.
Source:
Archives of virology 1999 v.144 no.1 pp. 45-54
ISSN:
0304-8608
Subject:
CD8-positive T-lymphocytes, chickens, serotypes, vaccines, viruses
Abstract:
To know the effect of Marek’s disease (MD) vaccines, we analyzed the distribution of MD virus (MDV) among T cell subsets from chickens vaccinated or non-vaccinated with MD vaccine and subsequently challenged with a virulent MDV. The challenged MDV was reisolated preferentially from CD4⁺ T cells, and the average titers of challenged MDV rescued were significantly lower in vaccinated chickens compared to that of non-vaccinated chickens. In addition, it was also shown that different serotypes of MDV, CVI988 and SB-1, have remarkable difference in recovery rates of viruses from CD4+ and CD8+ T cells, though both CVI988 and SB-1 can reduce the infection rates of virulent MDV to splenocytes.
Agid:
650532