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Healthy Lifestyle and Incidence of Metabolic Syndrome in the SUN Cohort

Maria Garralda-Del-Villar, Silvia Carlos-Chillerón, Jesus Diaz-Gutierrez, Miguel Ruiz-Canela, Alfredo Gea, Miguel Angel Martínez-González, Maira Bes-Rastrollo, Liz Ruiz-Estigarribia, Stefanos N. Kales, Alejandro Fernández-Montero
Nutrients 2018 v.11 no.1 pp. -
Mediterranean diet, alcohol drinking, alcoholic beverages, binging, chronic diseases, cohort studies, confidence interval, health promotion, lifestyle, men, metabolic syndrome, odds ratio, physical activity, risk reduction, television, women
We assessed the relationship between a healthy lifestyle and the subsequent risk of developing metabolic syndrome. The &ldquo;Seguimiento Universidad de Navarra&rdquo; (SUN) Project is a prospective cohort study, focused on nutrition, lifestyle, and chronic diseases. Participants (n = 10,807, mean age 37 years, 67% women) initially free of metabolic syndrome were followed prospectively for a minimum of 6 years. To evaluate healthy lifestyle, nine habits were used to derive a Healthy Lifestyle Score (HLS): Never smoking, moderate to high physical activity (>20 MET-h/week), Mediterranean diet (&ge;4/8 adherence points), moderate alcohol consumption (women, 0.1&ndash;5.0 g/day; men, 0.1&ndash;10.0 g/day), low television exposure (<2 h/day), no binge drinking (&le;5 alcoholic drinks at any time), taking a short afternoon nap (<30 min/day), meeting up with friends >1 h/day, and working at least 40 h/week. Metabolic syndrome was defined according to the harmonizing definition. The association between the baseline HLS and metabolic syndrome at follow-up was assessed with multivariable-adjusted logistic regressions. During follow-up, we observed 458 (4.24%) new cases of metabolic syndrome. Participants in the highest category of HLS adherence (7&ndash;9 points) enjoyed a significantly reduced risk of developing metabolic syndrome compared to those in the lowest category (0&ndash;3 points) (adjusted odds ratio (OR) = 0.66, 95% confidence interval (CI) = 0.47&ndash;0.93). Higher adherence to the Healthy Lifestyle Score was associated with a lower risk of developing metabolic syndrome. The HLS may be a simple metabolic health promotion tool.