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Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs

Author:
Nordgren, Tara M., Anderson Berry, Ann, Van Ormer, Matthew, Zoucha, Samuel, Elliott, Elizabeth, Johnson, Rebecca, McGinn, Elizabeth, Cave, Caleb, Rilett, Katherine, Weishaar, Kara, Maddipati, Sai Sujana, Appeah, Harriet, Hanson, Corrine
Source:
Nutrients 2019 v.11 no.1
ISSN:
2072-6643
Subject:
biomarkers, biosynthesis, docosahexaenoic acid, food frequency questionnaires, mothers, omega-3 fatty acids, pregnancy
Abstract:
Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 fatty acids serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory and immune-stimulating effects. The role SPM play in the protection against negative maternal-fetal health outcomes is unclear, and there are no current biomarkers of n-3 fatty acid sufficiency. We sought to ascertain the relationships between n-3 fatty acid intake, SPM levels, and maternal-fetal health outcomes. We obtained n-3 fatty acid intake information from 136 mothers admitted for delivery using a food frequency questionnaire and measured docosahexaenoic acid (DHA)-derived SPMs resolvin D1 (RvD1) and RvD2 in maternal and cord plasma. We found significantly elevated SPM in maternal versus cord plasma, and increased SPM levels were associated with at-risk outcomes. We also identified that increased DHA intake was associated with elevated maternal plasma RvD1 (p = 0.03; R2 = 0.18) and RvD2 (p = 0.04; R2 = 0.20) in the setting of neonatal intensive care unit (NICU) admission. These findings indicate that increased n-3 fatty acid intake may provide increased substrate for the production of SPM during high-risk pregnancy/delivery conditions, and that increased maternal plasma SPM could serve as a biomarker for negative neonatal outcomes.
Agid:
6506818