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Trunculins X and Y from an Okinawan sponge Sigmosceptrella sp.

Author:
Hirade, Hiromi, de Voogd, Nicole J., Suzuka, Toshimasa, Tanaka, Junichi
Source:
Tetrahedron 2019 v.75 no.33 pp. 4620-4625
ISSN:
0040-4020
Subject:
chemical reactions, chemical structure, cytotoxicity, inhibitory concentration 50, organic compounds, peroxides, spectral analysis
Abstract:
Two new norsesterterpenoid cyclic peroxides, trunculins X and Y, were isolated from an Okinawan sponge Sigmosceptrella sp. Their structures were determined by spectroscopic analyses on intact molecules and derivatives and also by crystallographic study. The compounds showed cytotoxicity in a range of IC50 0.32–20 μM against three cell lines.
Agid:
6509370