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Trunculins X and Y from an Okinawan sponge Sigmosceptrella sp.
- Hirade, Hiromi, de Voogd, Nicole J., Suzuka, Toshimasa, Tanaka, Junichi
- Tetrahedron 2019 v.75 no.33 pp. 4620-4625
- chemical reactions, chemical structure, cytotoxicity, inhibitory concentration 50, organic compounds, peroxides, spectral analysis
- Two new norsesterterpenoid cyclic peroxides, trunculins X and Y, were isolated from an Okinawan sponge Sigmosceptrella sp. Their structures were determined by spectroscopic analyses on intact molecules and derivatives and also by crystallographic study. The compounds showed cytotoxicity in a range of IC50 0.32–20 μM against three cell lines.