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Iodine-catalyzed direct allylation of chiral oxazolidinones by the amide-aldehyde-alkene condensation

Author:
Wang, Tong-Lin, Qi, Hai-Tang, Wang, Xi-Cun, Quan, Zheng-Jun
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
aldehydes, alkenes, allylation, amines, catalytic activity, chromatography, diastereomers, metals, oxazolidinones
Abstract:
An iodine-catalyzed direct allylation of chiral oxazolidinones with aldehydes and alkenes has been developed. The reaction proceeds, without use of any bases or metals, directly converted the 3-chiral oxazolidinones into N-allylated oxazolidinones. Additionally, the 3-chiral allylamine skeleton was constructed and the diastereomers were isolated by simple column chromatography.
Agid:
6509393