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Preparation and characterization of electrospun poly(lactic acid)-chitosan core-shell nanofibers with a new solvent system

Afshar, Shahnoosh, Rashedi, Shiva, Nazockdast, Hossein, Ghazalian, Malihe
International journal of biological macromolecules 2019 v.138 pp. 1130-1137
Fourier transform infrared spectroscopy, acetic acid, curcumin, dimethylformamide, drugs, mechanical properties, nanofibers, polylactic acid, reflectance, scanning electron microscopy, solvents, thermogravimetry, transmission electron microscopy
Poly(lactic acid)-chitosan (PLA-CS) core-shell nanofibers were successfully fabricated by coaxial electrospinning technique using a new solvent system for the core and shell solutions, dimethylformamide for the core solution and trifluoro-acetic acid/acetic acid (90/10 v/v) for the shell solution. The formation of the core-shell structure of the nanofibers with this new solvent system was confirmed by transmission electron microscopy (TEM) and attenuated total reflectance Fourier transform spectroscopy (ATR-FTIR). Morphology of the as-spun nanofibers was investigated by scanning electron microscopy (SEM) which showed bead-free smooth PLA-CS core-shell type nanofibers with an average diameter of 671 ± 172 nm and a broad diameter distribution. Thermogravimetric analysis (TGA) indicated that although PLA content was less than CS in the core-shell nanofibrous mat (20.7% PLA vs. 39% CS) the presence of PLA in the core of nanofibers significantly improved their mechanical properties. The PLA-CS core-shell nanofibers showed a two-stage release behavior of curcumin drug; an initial burst release followed by a sustained release, when the drug was incorporated in the core layer of nanofibers; hence it has potential applications in some biomedical areas such as wound dressing and drug delivery.