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Plasmodium knowlesi: a relevant, versatile experimental malaria model
- PASINI, ERICA M., ZEEMAN, ANNE-MARIE, VOORBERG-VAN DER WEL, ANNEMARIE, KOCKEN, CLEMENS H. M.
- Parasitology 2018 v.145 no.1 pp. 56-70
- Macaca fascicularis, Macaca mulatta, Plasmodium knowlesi, erythrocytes, host-parasite relationships, hosts, humans, immunology, malaria, models, parasites, transfection, vaccine development, zoonoses, South East Asia
- The primate malaria Plasmodium knowlesi has a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite–host interactions. The adaptation to long-term in vitro continuous blood stage culture in rhesus monkey, Macaca fascicularis and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence that P. knowlesi is an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.