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Synthesis and application of a series of amphipathic chitosan derivatives and the corresponding magnetic nanoparticle-embedded polymeric micelles

Author:
Chu, Liqiu, Zhang, Yutong, Feng, Zhipan, Yang, Jueying, Tian, Qingquan, Yao, Xianping, Zhao, Xinqi, Tan, Huimin, Chen, Yu
Source:
Carbohydrate polymers 2019 v.223 pp. 114966
ISSN:
0144-8617
Subject:
amination, bioactive properties, chitosan, drug carriers, drugs, hydrophobic bonding, hydrophobicity, iron oxides, magnetism, micelles, models, nanoparticles, oils, pH, paclitaxel, polyethylene glycol, surfactants
Abstract:
Magnetic nanoparticle-embedded polymeric micelles (MNP-PMs) prepared with amphipathic polymers are an important sustained-release carrier for hydrophobic drugs. The amphipathic chitosan derivatives (ACDs) based stimuli-responsive slow-release carriers have attracted considerable attentions because of the bioactivities and modifiability of chitosan. In the current study, a series of ACDs including alkylated N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (alkyl-HTCC) and alkylated polyethylene glycol N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (alkyl-PEG-HTCC) were prepared by the reductive amination of HTCC and PEG-HTCC, and their structures and properties were characterized. Octyl-HTCC/O-Fe3O4 and octyl-PEG-HTCC/O-Fe3O4 MNP-PMs were prepared by the hydrophobic interactions between the corresponding ACDs and oil soluble Fe3O4 magnetic nanoparticles (O-Fe3O4 MNPs), and characterized for the structure, magnetic performance and surface charge state. Their potential application as a drug delivery carrier was investigated upon the embedding efficiency and pH dependent sustained-release performance using the hydrophobic drug, paclitaxel (PTX), as a model drug. Our work has provided a new application strategy of ACDs in the multi-functional drug delivery carrier.
Agid:
6515719