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Lipids from the Aerial Part of Scutellaria ramosissima

Author:
Yuldasheva, N. K., Ul’chenko, N. T., Mamadalieva, N., Glushenkova, A. I., Ovidi, E., Triggiani, D., Tiezzi, A.
Source:
Chemistry of natural compounds 2014 v.50 no.1 pp. 68-71
ISSN:
0009-3130
Subject:
Scutellaria, chlorophyll, cytotoxicity, glycolipids, inhibitory concentration 50, linoleic acid, phospholipids, tocopherols, triacylglycerols, United States
Abstract:
Total lipids (TL) (2.1%), more than half of which were glycolipids (GL) (1.3%), and neutral lipids (NL) (0.54%) and phospholipids (PL) (0.26%) were isolated from the air-dried aerial part of Scutellaria ramosissima. The principal acids of the NL were 16:0, 18:2, and 18:3. Acid 16:0 (up to 40 mass% of the acids) dominated the glycolipids. Palmitic and linoleic acids dominated the PL with 18:1 in combination with 18:3 comprising slightly greater than 31%, like linoleic acid. The chlorophyll content was 197.3 mg% in the total lipids; carotinoids, 157.1 mg%; tocopherols, 357.0 mg% in unsaponified substances (US). The cytotoxic activity of the S. ramosissima lipid fractions was tested on HL-60 and HeLa cancer cell lines using the MTT test. PL, NL, and US showed cytotoxicity for HL-60 cells with IC₅₀ values of 8.3, 22.0, and 24.3 μg/mL, respectively, and were inactive for HeLa cells. The GL and TL turned out to be slightly active.
Agid:
652237