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Experimental evidences that P21 protein controls Trypanosoma cruzi replication and modulates the pathogenesis of infection

Teixeira, Thaise L., Castilhos, Patrícia, Rodrigues, Cassiano C., da Silva, Aline A., Brígido, Rebecca TS., Teixeira, Samuel C., Borges, Bruna C., Dos Santos, Marlus A., Martins, Flávia A., Santos, Paulo César F., Servato, João Paulo S., Silva, M.S., da Silva, M.J.B., Elias, M.C., da Silva, Claudio V.
Microbial pathogenesis 2019 v.135 pp. 103618
Trypanosoma cruzi, amastigotes, angiogenesis, bioactive properties, cell cycle, chemotaxis, epimastigotes, fibrosis, leukocytes, mice, parasite load, parasites, pathogenesis, phagocytosis
P21 is a protein secreted by Trypanosoma cruzi (T. cruzi). Previous studies have shown a spectrum of biological activities performed by P21 such as induction of phagocytosis, leukocyte chemotaxis and inhibition of angiogenesis. However, the activity of P21 in T. cruzi infection remains unknown. Here, we reported the role of P21 in mice harboring late T. cruzi infection. Treatment with recombinant P21 protein (rP21) reduced parasite load and angiogenesis, and induced fibrosis in the cardiac tissue of infected mice. In addition, rP21 reduced the growth of epimastigotes, inhibited intracellular replication of amastigotes and modulated the parasite cell cycle. Our data suggest that P21 controls parasite replication in the host, supporting the survival of both parasite and host.