PubAg

Main content area

[4 + 2]-Annulation of MBH-Acetates of Acetylenic Aldehydes with Imidazoles/Benzimidazoles To Access Imidazo[1,2-a]pyridines/Benzimidazo[1,2-a]pyridines

Author:
Raji Reddy, Chada, Burra, Amarender Goud
Source:
Journal of organic chemistry 2019 v.84 no.14 pp. 9169-9178
ISSN:
1520-6904
Subject:
acetates, aldehydes, amination, benzimidazoles, chemical structure, imidazoles, organic chemistry, pyridines
Abstract:
An unprecedented one-pot successive base-mediated allylic amination/cycloisomerization reaction strategy has been developed to construct diversely substituted imidazo[1,2-a]pyridines and benzimidazo[1,2-a]pyridines in good to excellent yield. The advantage of this unique [4 + 2]-annulation lies in the employment of readily accessible starting materials, Morita–Baylis–Hillman acetates of acetylenic aldehydes as C4 synthons, and simple imidazoles or benzimidazoles as C2 synthons.
Agid:
6539142