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One-pot synthesis of trifluoromethyl amines and perfluoroalkyl amines with CF₃SO₂Na and RfSO₂Na

Author:
LiangThese authors contributed equally to this paper., Shuaishuai, Wei, Jingjing, Jiang, Lvqi, Liu, Jie, Mumtaz, Yasir, Yi, Wenbin
Source:
Chemical communications 2019 v.55 no.59 pp. 8536-8539
ISSN:
1364-548X
Subject:
chemical reactions, moieties, perfluorocarbons, secondary amines, synthesis
Abstract:
A newly developed CF₃SO₂Na-based trifluoromethylation of secondary amines has been disclosed, and the method has been successfully extended to the configuration of perfluoroalkyl amines using RfSO₂Na, complementing the established synthesis strategy of trifluoromethyl amines. Advantages of the method include good functional group tolerance, mild conditions, and inexpensive or easy-to-handle materials. Mechanistic probes indicate that the thiocarbonyl fluoride formed in situ is the key intermediate in the reaction.
Agid:
6539537