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Cascade cyclization and acyl migration of propargylic esters with isocyanides: rapid access to substituted furans

Author:
Hu, Jie, Fei, Youwen, Zhao, Hongbin, Wang, Zhishuang, Li, Chunju, Li, Jian
Source:
Chemical communications 2019 v.55 no.58 pp. 8394-8397
ISSN:
1364-548X
Subject:
acetates, cyclization reactions, furans
Abstract:
A novel rearrangement of ester-activated propargylic acetate with isocyanide has been disclosed. This protocol enables a quick synthesis of polysubstituted furan derivatives. The reaction outcome also reveals that the ester group is employed for the construction of a furan ring and an acyl migration is observed.
Agid:
6539546