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Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H₂O as a stoichiometric hydrogen atom donor
- Li, Qifan, Jiao, Xiaoyang, Xing, Mimi, Zhang, Penglin, Zhao, Qian, Zhang, Chun
- Chemical communications 2019 v.55 no.59 pp. 8651-8654
- aldehydes, catalytic activity, chemical reactions, hydrogen, moieties, reducing agents
- A copper-catalyzed highly regio- and diastereo-selective reductive reaction of terminal 1,3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor. In this transformation, B₂Pin₂, a mild and practical kind of reductant was used as the mediator. The reaction pathway of this practical strategy was illustrated by a control experiment.