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Lignans from Schisandra chinensis rattan stems suppresses primary Aβ₁₋₄₂-induced microglia activation via NF-κB/MAPK signaling pathway

Author:
Yang, Bingyou, Han, Wei, Han, Hua, Liu, Yan, Guan, Wei, Kuang, Haixue
Source:
Natural product research 2019 v.33 no.18 pp. 2726-2729
ISSN:
1478-6427
Subject:
Calamus, IKappaB kinase, Schisandra chinensis, amyloid, amyloid beta-peptides, inflammation, interleukin-1beta, lignans, mitogen-activated protein kinase, models, neurodegenerative diseases, neuroglia, phosphorylation, signal transduction, stems, transcription factor NF-kappa B, tumor necrosis factor-alpha
Abstract:
Microglia cells play important roles in neurodegenerative diseases for clearing amyloid-β and reducing the occurrence of inflammation. In this study, the neuroinflammatory effect and the mechanism of lignans from Schisandra chinensis rattan stems (rsSCH-L) were evaluated by Aβ₁₋₄₂-induced primary microglia cell model. The results have shown that rsSCH-L could reduce the levels of pro-inflammatory cytokines, including IL-1β, TNF-α and NO. Moreover, rsSCH-L suppressed the phosphorylations of NF-κB and IκBα as well as p38, JNK and ERK proteins in Aβ₁₋₄₂-induced microglia cells. Taken together, rsSCH-L could attenuate microglia cells from neuroinflammation by activating the NF-κB/MAPK signaling pathway.
Agid:
6541161