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Insecticidal and α-glucosidase inhibitory activities of chemical constituents from Viburnum fordiae Hance

Author:
Shao, Jian-Hua, Chen, Jia, Zhao, Chun-Chao, Shen, Jie, Liu, Wen-Yan, Gu, Wen-Yan, Li, Ke-Huan
Source:
Natural product research 2019 v.33 no.18 pp. 2662-2667
ISSN:
1478-6427
Subject:
Mythimna separata, Viburnum, alcohols, alpha-glucosidase, chemical composition, enzyme inhibition, fractionation, glycosides, inhibitory concentration 50, lethal dose 50, nuclear magnetic resonance spectroscopy, spectral analysis, stems
Abstract:
The ethanolic extract of the stems of Viburnum fordiae Hance showed insecticidal and α-glucosidase inhibitory activities and then was fractionated by bioactivity-guided fractionation to obtain a rare C₁₃-norisoprenoid (1), together with a new phenolic glycoside (2), and seven known compounds, alangionoside C (3), pisumionoside (4), koaburaside (5), 3,5-dimethoxy-benzyl alcohol 4-O-β-d-glucopyranoside (6), 3,4,5-trimethoxybenzyl-β-d-glucopyranoside (7), arbutin (8), and salidroside (9). The previously undescribed compounds were elucidated as (3R,9R)-3-hydroxy-7,8-didehydro-β-ionyl 9-O-α-d-arabinopyranosyl-(1→6)-β-d-glucopyranoside (1) and 2-(4-O-β-d-glucopyranosyl)syringylpropane-1,3-diol (2) by spectroscopic data (¹H and ¹³C NMR, HSQC, HMBC, ¹H-¹H COSY, HSQC-TOCSY, HRESIMS, IR and ORD) and chemical methods. Compound 1 showed potent insecticidal effect against Mythimna separata with LD₅₀ value of 140 μg g⁻¹. Compounds 2, 5, 6, 8 and 9 showed varying α-glucosidase inhibitory activity with IC₅₀ values ranging from 148.2 to 230.9 μM.
Agid:
6541163