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Probiotic Ingestion, Obesity, and Metabolic-Related Disorders: Results from NHANES, 1999–2014

Lau, Eva, Neves, João Sérgio, Ferreira-Magalhães, Manuel, Carvalho, Davide, Freitas, Paula
Nutrients 2019 v.11 no.7
National Health and Nutrition Examination Survey, adults, body mass index, cross-sectional studies, diastolic blood pressure, diet recall, dietary supplements, dysbiosis, high density lipoprotein, hyperlipidemia, hypertension, intestinal microorganisms, noninsulin-dependent diabetes mellitus, obesity, odds ratio, probiotics, questionnaires, triacylglycerols, yogurt
Gut microbiota dysbiosis has been recognized as having key importance in obesity- and metabolic-related diseases. Although there is increasing evidence of the potential benefits induced by probiotics in metabolic disturbances, there is a lack of large cross-sectional studies to assess population-based prevalence of probiotic intake and metabolic diseases. Our aim was to evaluate the association of probiotic ingestion with obesity, type 2 diabetes, hypertension, and dyslipidemia. A cross-sectional study was designed using data from the National Health and Nutrition Examination Survey (NHANES), 1999&ndash;2014. Probiotic ingestion was considered when a subject reported consumption of yogurt or a probiotic supplement during the 24-h dietary recall or during the Dietary Supplement Use 30-Day questionnaire. We included 38,802 adults and 13.1% reported probiotic ingestion. The prevalence of obesity and hypertension was lower in the probiotic group (obesity-adjusted Odds Ratio (OR): 0.84, 95% CI 0.76&ndash;0.92, p < 0.001; hypertension-adjusted OR: 0.79, 95% CI 0.71&ndash;0.88, p < 0.001). Accordingly, even after analytic adjustments, body mass index (BMI) was significantly lower in the probiotic group, as were systolic and diastolic blood pressure and triglycerides; high-density lipoprotein (HDL) was significantly higher in the probiotic group for the adjusted model. In this large-scale study, ingestion of probiotic supplements or yogurt was associated with a lower prevalence of obesity and hypertension.