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Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats

Author:
Wang, Shao-Yuan, Li, Mei, Miao, Lu-Yang, Wu, Song, Tong, Yuan-Feng, Zhang, Wen-Xuan, Zhang, Yu-Yang, Sun, Hua
Source:
Journal of Asian natural products research 2019 v.21 no.9 pp. 928-938
ISSN:
1477-2213
Subject:
apoptosis, biphenyl, blood serum, enzymes, interleukin-6, intravenous injection, laboratory animals, lipopolysaccharides, liver failure, liver function, mortality, protective effect, rats, swine, therapeutics, tumor necrosis factor-alpha, water solubility
Abstract:
This study investigated the therapeutic effects of a water-soluble biphenyl compound, WLP-S-14, in acute-on-chronic liver failure (ACLF). Wistar rats were injected intraperitoneally with porcine serum twice a week for 8 weeks prior to administration of 600 mg/kg D-galactosamine and 50 μg/kg lipopolysaccharide to induce ACLF. Study groups were treated intravenously with saline or with 100 or 200 mg/kg WLP-S-14. WLP-S-14 ameliorated ACLF with significant reductions in the mortality rate and transaminase levels, indicating improved liver function. The mechanism underlying these effects may involve decreased levels of tumor necrosis factor-α and interleukin-6, with associated inhibition of apoptotic pathways.
Agid:
6546721