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Nanoparticle–Biofilm Interactions: The Role of the EPS Matrix
- Fulaz, Stephanie, Vitale, Stefania, Quinn, Laura, Casey, Eoin
- Trends in microbiology 2019 v.27 no.11 pp. 915-926
- anti-infective agents, antibiotic resistance, biofilm, extracellular matrix, nanoparticles
- The negative consequences of biofilms are widely reported. A defining feature of biofilms is the extracellular matrix, a complex mixture of biomacromolecules, termed EPS, which contributes to reduced antimicrobial susceptibility. EPS targeting is a promising, but underexploited, approach to biofilm control allowing disruption of the matrix and thereby increasing the susceptibility to antimicrobials. Nanoparticles (NPs) can play a very important role as ’carriers’ of EPS matrix disruptors, and several approaches have recently been proposed. In this review, we discuss the application of nanoparticles as antibiofilm technologies with a special emphasis on the role of the EPS matrix in the physicochemical regulation of the nanoparticle–biofilm interaction. We highlight the use of nanoparticles as a platform for a new generation of antibiofilm approaches.