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Emerging Roles for the Mitochondrial ATP Synthase Supercomplexes

Author:
Nesci, Salvatore, Pagliarani, Alessandra
Source:
Trends in biochemical sciences 2019 v.44 no.10 pp. 821-823
ISSN:
0968-0004
Subject:
H+/K+-exchanging ATPase, H-transporting ATP synthase, mammals, mitochondria
Abstract:
As pointed out by Gu et al. (Science 2019) in mammalian mitochondria, the H-shaped tetrameric structure of the ATP synthase, the cell powerhouse, consists of two V-shaped dimers linked by two IF1 in antiparallel arrangement. This supramolecular structure reveals new functional/structural roles of the enzyme complex in mitochondria.
Agid:
6553959