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An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity

Liang, Jia-Hao, Huo, Xiao-Kui, Cheng, Zhong-Bin, Sun, Cheng-Peng, Zhao, Jian-Chao, Kang, Xiao-Hui, Zhang, Tian-Yuan, Chen, Zhong-Jian, Yang, Tian-Mei, Wu, Ying-Ying, Deng, Xiao-Peng, Zhang, Yi-Xuan
Natural product research 2019 v.33 no.19 pp. 2770-2776
Bacillus cereus, Bacillus subtilis, Candida albicans, Klebsiella pneumoniae, Panax notoginseng, Pseudomonas aeruginosa, Staphylococcus aureus, antimicrobial properties, circular dichroism spectroscopy, computer simulation, culture media, diterpenoids, electrospray ionization mass spectrometry, enzymes, fungi, indoles, nuclear magnetic resonance spectroscopy, peptides, spectral analysis
One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.