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Among the water-soluble vitamins, dietary intakes of vitamins C, B₂ and folate are associated with the reduced risk of diabetes in Japanese women but not men

Author:
Eshak, Ehab S., Iso, Hiroyasu, Muraki, Isao, Tamakoshi, Akiko
Source:
The British journal of nutrition 2019 v.121 no.12 pp. 1357-1364
ISSN:
1475-2662
Subject:
Japanese people, antioxidant activity, ascorbic acid, body mass index, folic acid, food intake, men, noninsulin-dependent diabetes mellitus, prospective studies, protective effect, pyridoxine, regression analysis, riboflavin, risk, risk reduction, smoking (habit), thiamin, women
Abstract:
Recent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B₂ and homocysteine-lowering effects of vitamins B₆, folate and B₁₂ may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40–79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B₂ and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B₁, B₃, B₅, B₆ and B₁₂ were observed in either sex. The multivariable OR in the highest v. the lowest quartile of intakes among women were 0·61 (95 % CI 0·44, 0·94; P-trend = 0·04) for vitamin C, 0·56 (95 % CI 0·34, 0·93; P-trend = 0·03) for vitamin B₂ and 0·70 (95 % CI 0·46, 0·98; P-trend = 0·03) for folate. Other than that for sex (P < 0·05), the P-interactions with age, BMI, smoking status or having a family history of diabetes were >0·10. In conclusion, higher dietary intakes of vitamins C, B₂ and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women.
Agid:
6559947