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The regiospecific Fischer indole reaction in choline chloride·2ZnCl₂ with product isolation by direct sublimation from the ionic liquid

Author:
Calderon Morales, Raul, Tambyrajah, Vasuki, Jenkins, Paul R., Davies, David L., Abbott, Andrew P.
Source:
Chemical communications 2004 no.2 pp. 158-159
ISSN:
1364-548X
Subject:
chemical reactions, choline chloride, indoles, ionic liquids, ketones, regioselectivity, sublimation
Abstract:
The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride·2ZnCl₂; exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.
Agid:
6574779