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A New Totarane Diterpenoid from the Rhizomes of Isodon lophanthoides

Author:
Xu, Wei, Xiao, Chao-Jiang, Sun, Jun-Zhe, Zhang, Pan-Pan, Wang, Jing-Wen, Dong, Xiang, Jiang, Bei
Source:
Chemistry of natural compounds 2019 v.55 no.4 pp. 685-688
ISSN:
0009-3130
Subject:
Isodon lophanthoides, acetone, chemistry, diterpenoids, rhizomes, spectral analysis, triterpenoids
Abstract:
A new totarane diterpenoid, 7β,15-dihydroxytotarol-19-oic acid (1), along with six known diterpenoids (2–7) and seven known triterpenoids (8–14), were isolated from the EtOAc-soluble fraction of the 70% acetone extract of rhizomes of Isodon lophanthoides. Their structures were elucidated based on the analysis of extensive spectroscopic data. The antimalarial activities of all the isolated diterpenoids were measured by the β-hematin formation inhibition assay in vitro. Compounds 2 and 4 showed moderate activities.
Agid:
6579549