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Three new labdane-type diterpenoids from Callicarpa macrophylla Vahl.

Author:
Wang, Zhen-Hui, Xu, Huan-Jun, Zhai, Yang-Yang, Yang, Lan-Ping, Li, Qiang, Huang, Mei, Chen, Xing-Ying, Zhang, Wen-Kui, Meng, Yue-Li, Zhang, Qing-Ling, Niu, Chao, Zhang, Yan-Ru
Source:
Natural product research 2019 v.33 no.20 pp. 2904-2910
ISSN:
1478-6427
Subject:
Callicarpa macrophylla, diterpenoids, inhibitory concentration 50, macrophages, nitric oxide, spectroscopy
Abstract:
Three new labdane-type diterpenoids, callicapene M3-M5 (1–3) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1–3 showed potent inhibitory activity, with IC₅₀ value of 48.15, 46.31 and 38.72 μM respectively.
Agid:
6582621