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Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N⁸-citryl-spermidine and its N¹-(3,4-dihydroxybenzoyl) derivative
- Oves-Costales, Daniel, Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Wilson, Keith S., Challis, Gregory L.
- Chemical communications 2008 no.34 pp. 4034-4036
- Bacillus anthracis, biosynthesis, catalytic activity, chemical reactions, siderophores, spermidine
- The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N¹-(3,4-dihydroxbenzoyl)-spermidine, with N⁸-citryl-spermidine or N¹-(3,4-dihydroxbenzoyl)-N⁸-citryl-spermidine, suggesting that N¹-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.