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Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

Author:
Jia, Yi-Xia, Hillgren, J. Mikael, Watson, Emma L., Marsden, Stephen P., Kündig, E. Peter
Source:
Chemical communications 2008 no.34 pp. 4040-4042
ISSN:
1364-548X
Subject:
arylation, carbenes, catalytic activity, enantioselectivity, heterocyclic nitrogen compounds, ligands, palladium
Abstract:
The Pd-catalysed asymmetric intramolecular α-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.
Agid:
6583087