Jump to Main Content
Platinum(ii) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity
- Zuqin Xue, Miaoxin Lin, Jianhui Zhu, Junfeng Zhang, Yizhi Li, Zijian Guo
- Chemical communications 2010 v.46 no.8 pp. 1212-1214
- animal ovaries, antineoplastic activity, apoptosis, aqueous solutions, cell lines, chemical communication, chemical reactions, cisplatin, crystal structure, cytotoxicity, humans, moieties, osteosarcoma, ovarian neoplasms, phosphonates, platinum, solubility
- Platinum(ii) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.