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Platinum(ii) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity

Author:
Zuqin Xue, Miaoxin Lin, Jianhui Zhu, Junfeng Zhang, Yizhi Li, Zijian Guo
Source:
Chemical communications 2010 v.46 no.8 pp. 1212-1214
ISSN:
1364-548X
Subject:
animal ovaries, antineoplastic activity, apoptosis, aqueous solutions, cell lines, chemical communication, chemical reactions, cisplatin, crystal structure, cytotoxicity, humans, moieties, osteosarcoma, ovarian neoplasms, phosphonates, platinum, solubility
Abstract:
Platinum(ii) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.
Agid:
6585700