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Photo-Irresponsive Molecule-Amplified Cell Release on Photoresponsive Nanostructured Surfaces

Li, Guannan, Wang, Hongyi, Zhu, Zhongpeng, Fan, Jun-Bing, Tian, Ye, Meng, Jingxin, Wang, Shutao
ACS applied materials & interfaces 2019 v.11 no.33 pp. 29681-29688
cell adhesion, hydrophilicity, neoplasm cells, neoplasms, tissue engineering, topology, wettability
Cell manipulation has raised extensive concern owing to its underlying applications in numerous biological situations such as cell–matrix interaction, tissue engineering, and cell-based diagnosis. Generally, light is considered as a superior candidate for manipulating cells (e.g., cell release) due to their high spatiotemporal precision and non-invasion. However, it remains a big challenge to release cells with high efficiency due to their potential limitation of the light-triggered wettability transition on photoresponsive surfaces. In this study, we report a photoresponsive spiropyran-coated nanostructured surface that enables highly efficient release of cancer cells, amplified by the introduction of a photo-irresponsive molecule. On one hand, structural recognition stems from topological interaction between nanofractal surfaces and the protrusions of cancer cells. On the other, molecular recognition can be amplified by a photo-irresponsive and hydrophilic molecule by reducing the steric hindrance of photoresponsive components and resisting nonspecific cell adhesion. Therefore, this study may afford a novel avenue for developing advanced smart materials for high-quality biological analysis and clinical diagnosis.