PubAg

Main content area

A facile dopamine-mediated metal-catecholamine coating for therapeutic nitric oxide gas interface-catalytic engineering of vascular devices

Author:
Song, Qiang, Li, Long, Xiong, Kaiqin, Tian, Wenjie, Lu, Jing, Wang, Jin, Huang, Nan, Tu, Qiufen, Yang, Zhilu
Source:
Biomaterials science 2019 v.7 no.9 pp. 3741-3750
ISSN:
2047-4849
Subject:
blood, catalytic activity, chelation, coatings, coordination compounds, endothelial cells, nitric oxide, smooth muscle, stainless steel, therapeutics, thiols, toxic substances
Abstract:
Developing a facile and versatile strategy to endow blood-contacting devices with surface in situ nitric oxide (NO) generation properties by catalytically decomposing endogenously existing S-nitrosothiols (RSNO) from blood is of immense scientific and engineering interest. However, most available strategies involve drawbacks of low efficiency, complex processes, and toxic chemicals. In this work, we report a facile method to deposit a NO-generating coating on a 316L stainless steel (SS) substrate through dopamine-mediated one-step assembly of Cuᴵᴵ-dopamine (Cuᴵᴵ-DA) coordination complexes. The chelation of Cuᴵᴵ in the Cuᴵᴵ-DA network endowed the coating with high in situ NO catalytic capacity by decomposing RSNO endogenously existing in blood. Of special importance is that this dopamine-mediated method possesses the merits of a simple preparation process, friendliness to the environment, high controllability of the Cuᴵᴵ-DA surface chemistry, highly effective surface coating formation, and long-term and durable catalytic activity of NO. The continuous release of NO from the Cuᴵᴵ-DA-coated 316L SS impressively improved its antithrombogenicity and selectively enhanced endothelial cell (EC) growth while inhibiting smooth muscle cell (SMC) proliferation.
Agid:
6603003