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Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota

Hu, Shiwei, Xu, Yangli, Gao, Xiang, Li, Shijie, Jiang, Wei, Liu, Yu, Su, Laijin, Yang, Huicheng
Marine drugs 2019 v.17 no.8
Bacteroides, Bifidobacterium, G-protein coupled receptors, Holothuroidea, Lactobacillus, Proteobacteria, Verrucomicrobia, adipokines, bacteria, blood serum, dietary supplements, digestive system, humans, hyperglycemia, intestinal microorganisms, mice, obesity, short chain fatty acids
This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.