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An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole

Author:
Mou, Xue-Qing, Xu, Zheng-Liang, Wang, Shao-Hua, Zhu, Dao-Yong, Wang, Jie, Bao, Wen, Zhou, Shi-Jiang, Yang, Chao, Zhang, Di
Source:
Chemical communications 2015 v.51 no.60 pp. 12064-12067
ISSN:
1364-548X
Subject:
catalytic activity, cyclization reactions, gold, primary amines, pyrroles
Abstract:
An Au(i)-catalyzed tandem reaction for the synthesis of 2-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole derivatives from 1-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclobutanol and primary amines or NH₄OAc has been developed to afford a series of polysubstituted pyrroles in moderate to good yields.
Agid:
6610160