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Microextraction of Gadolinium MRI contrast agent using core-shell Fe3O4@SiO2 nanoparticles: optimization of adsorption conditions and in-vitro study

Naghizadeh, Matin, Taher, Mohammad Ali, Tamaddon, Ali-Mohammad, Borandeh, Sedigheh, Abolmaali, Samira Sadat
Environmental nanotechnology, monitoring & management 2019 v.12 pp. 100250
Fourier transform infrared spectroscopy, X-ray diffraction, adsorbents, adsorption, coprecipitation, drugs, gadolinium, heavy metals, in vitro studies, light scattering, magnetic resonance imaging, magnetism, magnetite, microextraction, nanocomposites, nanoparticles, pH, purification methods, scanning electron microscopy, silica, transmission electron microscopes, transmission electron microscopy, ultrasonic treatment
Fe3O4 nanoparticles have been explored as highly efficient materials for heavy metal ion removal by adsorption process. In this contribution, a novel core–shell Fe3O4@SiO2 nanoparticle was prepared through chemical co-precipitation of SiO2@3-[2-(2-aminoethylamino)ethylamino]propyl-trimehoxysilane (AAAPTS) onto Fe3O4 magnetic nanoparticle surface. The structure and different properties of the synthesized nanocomposite were investigated using Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), Field emission-scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), Dynamic light scattering (DLS), and a Vibrating Sample Magnetometer (VSM). The results confirmed the successful preparation of magnetite nanocomposite and anchoring of Fe3O4 nanoparticles. To remove Gd (III) ion-containing Omniscan (gadodiamide) solution, the prepared Fe3O4@SiO2@AAAPTS nanoparticle was applied as a sorbent. The effects of different parameters on adsorption capacity, such as pH, acid concentration, the type and amount of adsorbent, and contact and ultrasonication times were optimized under optimum conditions. A limit of 1.4 ng L−1 was obtained for detection. The linear range was between 0.02 and 0.71 ng mL−1 with the relative SD of ±3.1% for the 8 replicates (0.07 ng mL−1) of Gd (III) based on this approach. The nanosorbent demonstrated cell compatibility at concentrations as high as 300 μg/mL. As a result, this method is believed to provide a wide application in the drug purification process of Magnetic resonance imaging (MRI) contrast agents such as Omniscan.