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Clicking dendritic peptides onto single walled carbon nanotubes

Author:
Moore, Eli, Wang, Peng-Yuan, Vogt, Andrew P., Gibson, Christopher T., Haridas, Vattekat, Voelcker, Nicolas H.
Source:
RSC advances 2012 v.2 no.4 pp. 1289-1291
ISSN:
2046-2069
Subject:
alkynes, azides, biocompatibility, carbon nanotubes, catalytic activity, cell culture, cycloaddition reactions, mesenchymal stromal cells, peptides, rats
Abstract:
Here, we demonstrate a straightforward click-chemistry-based approach for the functionalisation of single walled carbon nanotubes with oligo-lysine dendrons. Azide-functionalised nanotubes were reacted with alkyne-focal dendrons using the 1,3 dipolar Cu-catalysed azide alkyne cycloaddition reaction. Peptide dendron functionalised nanotubes showed significantly increased biocompatibility in rat mesenchymal stem cell culture.
Agid:
6640365