Jump to Main Content
Assembly–disassembly driven “off–on” fluorescent perylene bisimide probes for detecting and tracking of proteins in living cells
- Bo, Fuli, Gao, Baoxiang, Duan, Wenfeng, Li, Hongxia, Liu, Hongmei, Bai, Qianqian
- RSC advances 2013 v.3 no.38 pp. 17007-17010
- aqueous solutions, fluorescence, fluorescent dyes, nanomaterials, proteins
- We have developed an assembly–disassembly driven “off–on” fluorescent bioprobe based on amphiphilic perylene bisimide. In aqueous solutions, the amphiphilic probes can form self-assembled nanostructures with quenched fluorescence. These probes could then be disassembled by the binding of the probes to the targeted proteins, and the disassembly process leads to a 23-fold enhancement in fluorescence intensity. Amphiphilic perylene bisimides could be used as probes for the detection and tracking of targeted proteins under live cell conditions.