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Pd-catalyzed ligand-free Suzuki reaction of β-substituted allylic halides with arylboronic acids in water

Author:
Dong, Chaonan, Zhang, Lingjuan, Xue, Xiao, Li, Huanrong, Yu, Zhiyong, Tang, Weijun, Xu, Lijin
Source:
RSC advances 2014 v.4 no.22 pp. 11152-11158
ISSN:
2046-2069
Subject:
Suzuki reaction, acids, aromatic hydrocarbons, boronic acids, catalysts, catalytic activity, moieties, organic halogen compounds, palladium, potassium hydroxide
Abstract:
The catalyst system consisting of Pd(TFA)₂ and KOH allows for a wide range of β-substituted allylic halides to react efficiently with various arylboronic acids in neat water under ligand-free conditions, affording the allylated arenes in high yields with broad functional group tolerance and up to 7.4 × 10⁵ TON and 15 416 h⁻¹ TOF.
Agid:
6648559