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Freeze-drying synthesis, characterization and in vitro bioactivity of chitosan/graphene oxide/hydroxyapatite nanocomposite
- Mohandes, F., Salavati-Niasari, M.
- RSC advances 2014 v.4 no.49 pp. 25993-26001
- Fourier transform infrared spectroscopy, X-ray diffraction, bioactive properties, body fluids, calcium, chemical composition, chitosan, freeze drying, graphene oxide, hydroxyapatite, ions, monitoring, nanocomposites, nanoparticles, scanning electron microscopy, schiff bases, soaking, transmission electron microscopy
- Polycrystalline and dispersed hydroxyapatite (HAP) nanoparticles were successfully prepared via a simple precipitation method with the aid of a new capping agent based on Schiff base compounds. After that, a composite of chitosan (CT), graphene oxide (GO) and HAP nanoparticles was synthesized by a freeze-drying method. The as-produced Schiff base, HAP nanoparticles, and CT/GO/HAP nanocomposite were analysed by several techniques including FTIR, SEM, HR-TEM, and XRD. In addition, the in vitro bioactivity of HAP nanoparticles and the CT/GO/HAP nanocomposite was evaluated by soaking them in simulated body fluid (SBF). By monitoring the changes of chemical composition of the SBF solutions, it was concluded that more Ca and P ions were released from the CT/GO/HAP nanocomposite compared to the pure HAP nanoparticles, indicating a high bioactivity of the nanocomposite. The SEM images showed that the formation and growth of apatite on the surfaces of the products increased after immersion for 14 days in SBF.