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Peptidoglycan pathways: there are still more!
- Helal, Ahmed M., Sayed, Ahmed M., Omara, Mariam, Elsebaei, Mohamed M., Mayhoub, Abdelrahman S.
- RSC advances 2019 v.9 no.48 pp. 28171-28185
- World Health Organization, antibiotics, bacterial proteins, peptidoglycans
- The discovery of 3ʳᵈ and 4ᵗʰ generations of currently existing classes of antibiotics has not hindered bacterial resistance, which is escalating at an alarming global level. This review follows WHO recommendations through implementing new criteria for newly discovered antibiotics. These recommendations focus on abandoning old scaffolds and hitting new targets. In light of these recommendations, this review discusses seven bacterial proteins that no commercial antibiotics have targeted yet, alongside their reported chemical scaffolds.