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Ultratrace detection of glucose with enzyme-functionalized single nanochannels

Author:
Hou, Guanglei, Zhang, Huacheng, Xie, Ganhua, Xiao, Kai, Wen, Liping, Li, Shuhong, Tian, Ye, Jiang, Lei
Source:
Journal of materials chemistry A 2014 v.2 no.45 pp. 19131-19135
ISSN:
2050-7496
Subject:
blood glucose, enantiomers, enzymes, glucose, polymers
Abstract:
A sensitive nano-device for d-glucose detection is prepared by modifying a single conical polymer nanochannel with GOx enzymes. The current–voltage (I–V) characterization suggests that the nano-device responds to d-glucose rather than its enantiomer at concentrations down to 1 nM (10⁻⁹ mol L⁻¹). Moreover, the nano-device exhibits good reproducibility and specificity for d-glucose and is an ideal candidate for commercial non-invasive blood glucose meters in the future.
Agid:
6708793